Alessandra Ambrosio Paris Style

Alessandra Ambrosio Paris Style

The first step of the synthesis was to form the five-element ring. Next, scientists either closed the beta-lactam ring and added the amide with a side chain attached, or attached the amide with a side chain and then used a carbodiimide to close the beta-lactam ring. One important consideration was the groups attached to the first compounds used to form the five-element ring. Those groups were to protect the ring and the nitrogen and carbonyl groups so that they would be active at the time to close the beta-lactam ring. The protecting groups also had to be easy to remove after their task was accomplished. Sheehan found several protecting groups that worked. One bulky group also helped close the beta-lactam ring.

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